It adheres to all protective ventilation principles and is safe for patients both in terms of ventilation and in other respects, including electrical safety and the biocompatibility of the materials used. Another aim is easy and quick manufacturability using commercially available parts so that manufacturing is not jeopardized by issues in the supply of special parts. Considering the course of the disease with respiratory failure caused by SARS-CoV-2, the device has been engineered with a single ventilation regimen suitable for patients with ARDS. Other objectives include intuitive and simple operation and the use of consumables commonly available in anaesthesiology, resuscitation, and intensive care units.

‍

Patients with this respiratory disease require deep sedation during artificial lung ventilation. Given these basic pathophysiological aspects, CoroVent features a volume-controlled pressure-limited ventilation regimen with emphasis on configuring ventilation parameters to best meet the recommendations for so-called protective ventilation.

‍ 

The ventilator has a single ventilation regimen: volume-controlled pressure-limited ventilation. The ventilator works as a constant pressure source in inspiration,while expiration is controlled by a pneumatic valve that maintains the required PEEP and serves as a safety valve to prevent excessive Plim pressure in the patient circuit. The ventilator has two user interfaces on the front panel: an intuitive touch screen and rotary control knobs.

The device allows mandatory ventilation only without the possibility of triggering the patient’s breathing effort.

CoroVent is housed in a durable stainless-steel case ideal for the emergency room setting.

‍

‍

• intended for artificial lung ventilation of intubatedpatients
• intended for use by the healthcare providers
• intended for use in professional medical facilities
• allows medical oxygen dosing in the range of 21–100%
• equipped with a backup battery for a minimum of 20minutes of operation without any external power supply

Adjustable parameters

• tidal volume VT (ml)
• respiratory rate RR (bpm)
• oxygen inspiratory fraction FiO2
• inspiratory to expiratory time ratio I:E
• positive end exhalation pressure PEEP (cmH2O)
• maximum inspiratory pressure Pmax (cmH2)

‍

Measurable parameters

• inspiratory volume VTi (ml)
• expiratory volume VTe (ml)
• inspiratory to expiratory time ratio I:E
• maximum inspirator pressure Pmax (cmH2O)
• positive end exhalation pressure PEEP (cmH2O)
• inspiratorytime to total breath cycle time Ti/T

‍

Patient safety is a top priority in the design and construction of CoroVent.

The ventilator is designed to allow observation of protective ventilation principles and is thus equipped with the following features:

• fine adjustment of PEEP and its accurate monitoring with a wide range
• maximum/peak pressure control in the patient circuit adjustable by the user; in addition, the ventilator measures the plateau pressure Pplat
• adjustment of tidal volumes with a wide range to cover a broad spectrum of patients based on predicted body weight
• precise mixing of air and oxygen ensuring a stable desired fraction of oxygen in the airways

‍

The device has been engineered so that even in a single fault or undesirable condition caused by its operation (e.g. complete occlusion of the expiratory limbs of the patient circuit) it will not damage the patient’s respiratory system.

‍

Some of the components are disposable to prevent transmission of the highly contagious infection.

In addition to the common consumables used for patients on invasive artificial lung ventilation, use of CoroVent requires the following items:

• patient circuit (with passive humidification) – a standard consumable,
• filter with heat and moisture exchanger (HME) – a standard consumable,
• expiratory valve with connection hose for pressure control (CoroExsp, MICo type,CR),
• spirometer probe/sensor (CoroQuant, MICo type, CR).

The spirometer sensor and expiratory valve were specially designed by the CoroVent team, and MICo Medical ensures manufacture in sufficient quantities.